Coronary heart disease; lipid abnormalities as predictor in offspring of premature coronary heart disease patients

This study was conducted to perform serum lipid profile in off springs of premature coronary heart disease [CHD] patients and age and sex matched normal controls and compare the results of two groups. A cross sectional study. 250 off springs of diagnosed premature CHD patients were selected from Punjab institute of cardiology, Lahore and Services hospital, Lahore. 50 age and sex matched normal controls were selected from different areas of Lahore. Serum total cholesterol [TC], serum triglycerides [TG] serum low density lipoprotein-cholesterol [LDC-c] and serum high density lipoprotein cholesterol [HDL-c] was performed. Serum TC, TG, LDL-c of off springs of premature CHD patients was increased as compared with normal controls. Serum HDL-c of all the subjects of off springs of premature CHD patients was decreased as compared with normal controls. Off springs of premature CHD patients are more prone to develop lipid abnormalities as compared with normal controls

Portal triad changes in liver associated with rapeseed oil diet supplemented with atherogenic element: an experimental study

This experimental study was designed to see the possible effects of rapeseed oil on liver morphology. For this purpose, 60 albino rats of eight weeks age were selected and divided into five groups of twelve animals each with equal number of males and females. Group I, normal control, was fed on synthetic diet, Group II was on low rapeseed oil diet only and group III was on low rapeseed + hypercholesterolemic diet. Group IV was on high rapeseed oil diet only and Group V was on high rapeseed oil + hypercholesterolemic diet for the next 24 weeks. Histological examination was done on H and E, reticulin, trichrome and oil red O stains. Liver revealed mild to severe type of Portal triad fibrosis in groups II, III, IV and V. These findings were statistically significant when compared with control Group I. While bile duct proliferation [BDP] was mild in Group II and IV. Hence it is concluded that Rapeseed oil proved to be beneficial diet. It causes mild hepatic injury in low and high concentration. Hypercholesterolemic diet causes moderate to severe morphological changes in liver